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110 lines (100 loc) · 3.1 KB
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cff-version: 1.2.0
message: >
If you use pynetphorest in your research, please cite this software
alongside the foundational NetPhorest / KinomeXplorer, PTMcode v2,
and NetworKIN phosphorylation network discovery papers.
title: "pynetphorest: modern NetPhorest-style scoring and phosphorylation crosstalk modeling in Python"
version: "0.1.2"
type: software
authors:
- family-names: Mishra
given-names: Abhinav
email: mishraabhinav36@gmail.com
orcid: "https://orcid.org/0009-0005-3179-7408"
repository-code: "https://github.com/bibymaths/pynetphorest"
license: "BSD-3-Clause"
keywords:
- NetPhorest
- kinase
- phosphorylation
- crosstalk
- proteomics
- phosphoproteomics
- signal transduction
- network biology
abstract: >
pynetphorest is a modern Python toolkit that re-implements and extends
the NetPhorest family of methods, enabling scalable kinase–substrate
motif scoring, causal Writer→Reader inference, and machine-learning-based
phosphorylation crosstalk prediction. The package includes a unified CLI,
Snakemake workflows, threshold-sweep evaluation, and reproducible pipelines
for proteome-wide analysis using NetPhorest atlases and PTMcode2 phosphorylation
networks.
preferred-citation:
type: software
title: "pynetphorest"
authors:
- family-names: Mishra
given-names: Abhinav
year: 2025
version: "0.1.3"
repository-code: "https://github.com/bibymaths/pynetphorest"
references:
- type: article
title: "PTMcode v2: a resource for functional associations of post-translational modifications within and between proteins"
authors:
- family-names: Minguez
given-names: Pablo
- family-names: Letunic
given-names: Ivica
- family-names: Parca
given-names: Luca
- family-names: Garcia-Alonso
given-names: Luz
- family-names: Dopazo
given-names: Joaquin
- family-names: Huerta-Cepas
given-names: Jaime
- family-names: Bork
given-names: Peer
journal: "Nucleic Acids Research"
year: 2015
volume: "43"
issue: "Database issue"
pages: "D494–D502"
doi: "10.1093/nar/gku1081"
- type: article
title: "KinomeXplorer: an integrated platform for kinome biology studies"
authors:
- family-names: Horn
given-names: Heiko
- family-names: Schoof
given-names: Erwin M.
- family-names: Kim
given-names: Jinwoo
journal: "Nature Methods"
year: 2014
volume: "11"
pages: "603–604"
doi: "10.1038/nmeth.2968"
- type: article
title: "Systematic discovery of in vivo phosphorylation networks"
authors:
- family-names: Linding
given-names: Rune
- family-names: Jensen
given-names: Lars Juhl
- family-names: Ostheimer
given-names: Gernot J.
- family-names: van Vugt
given-names: Marcel A.
- family-names: Jørgensen
given-names: Claus
- family-names: Miron
given-names: I. Michael
journal: "Cell"
year: 2007
volume: "129"
issue: "7"
pages: "1415–1426"
doi: "10.1016/j.cell.2007.05.052"