diff --git a/packages/mui-material/src/ButtonBase/ButtonBase.js b/packages/mui-material/src/ButtonBase/ButtonBase.js
index bf5f9c0c3a9a91..39fd531b63daf5 100644
--- a/packages/mui-material/src/ButtonBase/ButtonBase.js
+++ b/packages/mui-material/src/ButtonBase/ButtonBase.js
@@ -192,7 +192,16 @@ const ButtonBase = React.forwardRef(function ButtonBase(inProps, ref) {
 
   const isNonNativeButton = () => {
     const button = buttonRef.current;
-    return component && component !== 'button' && !(button.tagName === 'A' && button.href);
+
+    if (!button) {
+      return component && component !== 'button';
+    }
+
+    if (button.tagName === 'BUTTON') {
+      return false;
+    }
+
+    return !(button.tagName === 'A' && button.href);
   };
 
   const handleKeyDown = useEventCallback((event) => {
@@ -240,7 +249,8 @@ const ButtonBase = React.forwardRef(function ButtonBase(inProps, ref) {
       event.target === event.currentTarget &&
       isNonNativeButton() &&
       event.key === ' ' &&
-      !event.defaultPrevented
+      !event.defaultPrevented &&
+      !disabled
     ) {
       event.currentTarget.click();
     }
diff --git a/packages/mui-material/src/ButtonBase/ButtonBase.test.js b/packages/mui-material/src/ButtonBase/ButtonBase.test.js
index 020dc9a3106815..c4e6322afcd57e 100644
--- a/packages/mui-material/src/ButtonBase/ButtonBase.test.js
+++ b/packages/mui-material/src/ButtonBase/ButtonBase.test.js
@@ -824,6 +824,32 @@ describe('<ButtonBase />', () => {
       setProps({ disabled: false });
       expect(button).not.to.have.attribute('aria-disabled');
     });
+
+    it('should not propagate click events when Space is released on a disabled non-native button', async () => {
+      const parentClickSpy = spy();
+      const buttonClickSpy = spy();
+
+      const { user } = render(
+        <div onClick={parentClickSpy}>
+          <ButtonBase component="span" disabled onClick={buttonClickSpy}>
+            Hello
+          </ButtonBase>
+        </div>,
+      );
+
+      const button = screen.getByRole('button');
+
+      // We don't use `user.tab()` because normal tab focus won't land on a disabled
+      // ButtonBase, only programmatic focus can happen
+      await act(async () => {
+        button.focus();
+      });
+
+      await user.keyboard(' ');
+
+      expect(buttonClickSpy.callCount).to.equal(0);
+      expect(parentClickSpy.callCount).to.equal(0);
+    });
   });
 
   describe('prop: component', () => {
@@ -1182,6 +1208,37 @@ describe('<ButtonBase />', () => {
         expect(onClickSpy.callCount).to.equal(0);
       });
 
+      it('should preserve native button keyboard behavior when a custom component renders a native button', async () => {
+        const onClickSpy = spy();
+        const onKeyDownSpy = spy();
+
+        /** @type {React.ForwardRefExoticComponent<React.ButtonHTMLAttributes<HTMLButtonElement>>} */
+        const MyButton = React.forwardRef((props, ref) => <button ref={ref} {...props} />);
+
+        const { user } = render(
+          <ButtonBase component={MyButton} onClick={onClickSpy} onKeyDown={onKeyDownSpy}>
+            Hello
+          </ButtonBase>,
+        );
+
+        await user.tab();
+
+        await user.keyboard('{Enter}');
+
+        expect(onKeyDownSpy.callCount).to.equal(1);
+        expect(onClickSpy.callCount).to.equal(1);
+        expect(onKeyDownSpy.firstCall.args[0]).to.have.property('defaultPrevented', false);
+
+        onClickSpy.resetHistory();
+        onKeyDownSpy.resetHistory();
+
+        await user.keyboard(' ');
+
+        expect(onKeyDownSpy.callCount).to.equal(1);
+        expect(onClickSpy.callCount).to.equal(1);
+        expect(onKeyDownSpy.firstCall.args[0]).to.have.property('defaultPrevented', false);
+      });
+
       it('prevents default on Enter with an anchor and empty href', async () => {
         const onClickSpy = spy();
         const onKeyDownSpy = spy();