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Many nice annotation tools are available in QuPath. Especially brush tool and wand tool with both additive and subtractive functions (by pressing Alt-key). These two tools are very useful in tissue detection and border control, e.g. using wand tool on different magnifications with different thresholds. QuPath also has a nice anti-overlapping annotation feature (I think pressing Alt+Control) which aligns annotations without crossing/overlapping.
https://qupath.readthedocs.io/en/latest/docs/starting/annotating.html
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